How's it going? (this means "How are you? not "Where are you going?"
How's everything?
How's life?
Asking about present activities
What's up?
What's happening?
Asking and telling about recent events
What's new?
Guess what? (I want to tell you something. Ask me about it)
Bringing up a serious topic
Can I talk to you for a minute?
Do you have a minute?
Got a minute?
